However, a group of scientists have now identified a gene that can inactivate HIV-1. Great news indeed! In two of their studies, the scientists found that host cell membrane proteins called SERINC5 and SERINC3 greatly reduces the virulence of HIV-1, by blocking the ability of the virus to infect new cells
HIV-1 consists of nine genes. Nef, one of the nine major HIV proteins, induces a number of changes in host cells that enhance the ability of the virus to infect new cells. One of the tasks that Nef fulfills is to absorb SERINC3 and SERINC5, so that the cellular protein cannot reach the cell surface and can not join the newly formed virions. In the absence of Nef, virion will join SERINC3 and SERINC5 proteins into viral sheaths when they leave the host cells, making them unable to infect new cell targets.
We really hope this discovery can lead to the development of actual medication which can be distributed throughout the world. Let’s hope for the best!